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but our algorithm is not for “the (1)” match, it’s designed to mark-and-sweep through all matches in the input, and looking back, the paper does not highlight the importance of this as much as it should. without pointing this out, we would have the slowest first match algorithm in the world.,这一点在51吃瓜中也有详细论述

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Since the eight reactions were run on fragments of random length, the eight plus and minus reactions collectively produced DNA fragments of all possible lengths.4 The fragments in these eight reactions were separated by size (using gel electrophoresis) and then imaged with autoradiography. Gels were dried and then placed against X-ray film, allowing the radioactive DNA fragments to expose the film and appear as dark bands, which a scientist could then painstakingly translate into the DNA sequence. In 1977, Sanger and colleagues sequenced the first full DNA genome using this method: a small bacterial virus with 5,386 nucleotides in its genome, called ɸX174 or “PhiX.”

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